Colorectal cancer is more than a simple genetic abnormality; it is a cancer that progresses through distortion of signaling networks that support cancer stem-cell maintenance and EMT-based invasion and metastasis.

In particular, the STAT3-centered signaling axis plays a key role in recurrence and metastasis by maintaining stemness and activating EMT.

BSP201 is a recombinant protein derived from the AI-powered BSP™ platform,
designed to regulate the STAT3–ZEB1–Sox2 signaling axis, a key driver of this pathology, at an upstream level.

By alleviating stemness- and EMT-related signals, BSP201 is designed to regulate key pathological processes involved in the growth and recurrence of colorectal cancer.

Mechanism-driven therapeutic strategy

• A mechanism-based anticancer therapeutic candidate designed to regulate pathology-maintaining signals,
  rather than directly killing cancer cells